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KMID : 1161420200230030297
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Journal of Medicinal Food
2020 Volume.23 No. 3 p.297 ~ p.304
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Effect of Ursolic Acid on Insulin Resistance and Hyperinsulinemia in Rats with Diet-Induced Obesity: Role of Adipokines Expression
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Gonzalez-Garibay Angelica S.
Lopez-Vazquez Alfonso
Garcia-Banuelos Jesus
Sanchez-Enriquez Sergio
Sandoval-Rodriguez Ana S.
Del Toro Arreola Susana
Bueno-Topete Miriam R.
Munoz-Valle Jose F.
Hita Mercedes E. Gonzalez
Dominguez-Rosales Jose A.
Armendariz-Borunda Juan
Bastidas-Ramirez Blanca E.
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Abstract
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Excess of visceral adipose tissue (VAT) characteristic of obesity leads to a proinflammatory state disrupting the insulin signaling pathway, triggering insulin resistance (IR) and inflammation, the main processes contributing to obesity comorbidities. Ursolic acid (UA), a pentacyclic triterpenoid occurring in a variety of plant foods, exhibits anti-inflammatory properties. The aim of this study was to evaluate UA effects on IR, hyperinsulinemia, and inflammation in experimental diet-induced obesity. Forty male Wistar rats were randomly assigned to eight groups (n?=?5). One group was used for time 0. Three groups were labeled as OBE (control): receiving high-fat diet (HFD; fat content 45.24% of energy) during 3, 6, or 9 weeks; three groups UA-PREV: exposed to simultaneous HFD and UA during 3, 6, or 9 weeks to evaluate UA preventive effects; one group UA-REV: receiving HFD for 6 weeks, followed by simultaneous HFD and UA for three additional weeks to analyze UA reversal effects. Measurements were performed after 3, 6, or 9 weeks of treatment. Adiposity was calculated by weighing VAT after sacrifice. Serum markers were quantified through colorimetric and enzyme-linked immunosorbent assay methods. VAT adipokines RNAm expression was evaluated by quantitative reverse transcriptase?polymerase chain reaction. Data were analyzed by Kruskal?Wallis and Mann?Whitney U tests. UA significantly decreased adiposity, IR, hyperinsulinemia, triacylglycerides, and cholesterol levels, and also VAT mRNA expression of MCP-1 (monocyte chemoattractant protein-1), IL (interleukin)-1β and IL-6, concomitantly increasing adiponectin levels. UA metabolic effects demonstrated in this study support its potential therapeutic utility to improve IR, hyperinsulinemia, and inflammation observed in obesity and diabetes.
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KEYWORD
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adiposity, dyslipidemia, nutraceutics, T2D
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